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Publications

Dana Beitner-Johnson, Ph.D.

Medline abstracts of any of these publications can be viewed by clicking on the following the links to Pubmed.

Original Research Articles Published:

1. Nelson, W.L., Olsen, L.D., Beitner, D.B., and Pallow, R.J. (1988) Regiochemistry and substrate stereoselectivity of O-demethylation of verapamil in the presence of the microsomal fraction from rat and human liver. Drug Metab and Disp, 16:184-188.

2. Beitner, D.B., Duman, R.S., and Nestler, E.J. (1989) A novel action of morphine in the rat locus coeruleus: persistent decrease in adenylate cyclase. Mol Pharmacol, 35:559-564.

3. Nestler, E.J., Terwilliger, R.Z., and Beitner, D.B. (1989) Regulation by chronic clonidine of adenylate cyclase and cyclic AMP-dependent protein kinase in the rat locus coeruleus. Life Sciences, 45:1073-1080.

4. Rasmussen, K., Beitner-Johnson, D.B., Krystal, J.H., Aghajanian, G.K., and Nestler, E.J. (1990) Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. J Neurosci, 10(7):2308-2317.

5. Guitart, X., Hayward, M., Nisenbaum, L.K., Beitner-Johnson, D.B.   Haycock, J.W., and Nestler, E.J. (1990) Identification of MARPP-58, a morphine- and cyclic AMP-regulated phosphoprotein of 58 kD as tyrosine hydroxylase: evidence for regulation of its expression by chronic morphine treatment in the rat locus coeruleus. J Neurosci, 10(8):2635-2645.

6. Terwilliger, R.Z., Beitner-Johnson, D., Sevarino, K.A., Crain, S.M., and Nestler, E.J. (1991) A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function. Brain Res, 548:100-110.

7. Beitner-Johnson, D. and Nestler, E.J. (1991) Morphine and cocaine exert common chronic actions on tyrosine hydroxylase in dopaminergic brain reward regions. J Neurochem, 57:344-347.

8. Beitner-Johnson, D., Guitart, X., and Nestler, E.J. (1991) Dopaminergic brain reward regions of Lewis and Fischer rats display different levels of tyrosine hydroxylase and other morphine- and cocaine-regulated phosphoproteins. Brain Res, 561:147-150.

9. Beitner-Johnson, D., Guitart, X., and Nestler, E.J. (1992) Neurofilament proteins and the mesolimbic dopamine system. I. Common regulation by chronic morphine and chronic cocaine in the rat ventral tegmental area. J Neurosci, 12:2165-2176.

10. Guitart, X., Beitner-Johnson, D., Marby, D.W., Kosten, T.A. and Nestler, E.J. (1992) Fischer and Lewis rat strains differ in basal levels of neurofilaments and in their regulation by chronic morphine in the mesolimbic dopamine system. Synapse, 12:242-253.

11. Beitner-Johnson, D., and Nestler, E.J. (1993) Chronic morphine decreases IGF-I levels in the ventral tegmental area of the rat brain. Ann NY Acad Sci, 692:246-248.

12. Beitner-Johnson, D., Guitart, X., and Nestler, E.J. (1993) Glial fibrillary acidic protein and the mesolimbic dopamine system: regulation by chronic morphine and Lewis-Fischer strain differences in the rat ventral tegmental area. J Neurochem, 61:1766-1773.

13. Beitner-Johnson, D., and Nestler, E.J. (1993) Chronic morphine impairs axoplasmic transport in the rat mesolimbic dopamine system. Neuroreport 5:57-60.

14. Beitner-Johnson, D., and LeRoith, D. (1995) IGF-I induces tyrosine phosphorylation of endogenous c-Crk, J Biol Chem, 270: 5187-5190.

15. Beitner-Johnson, D., Werner, H., Roberts, C.T., Jr., and LeRoith, D. (1995) Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and a CT element. Mol Endocrinol, 9: 1147-1156.

16. Berhow, M.T., Russel, D.S., Terwilliger, R.Z., Beitner-Johnson, D., Self, D.W., Lindsay, R.M., and Nestler, E.J. (1995) Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system. Neuroscience, 68: 969-979.

17. Self, D.W., McClenahan, A.W., Beitner-Johnson, D., Terwilliger, R.Z., and Nestler, E.J. (1995) Biochemical adaptations in the mesolimbic dopamine system in response to heroin self administration. Synapse, 21:312-318.

18. Beitner-Johnson. D., Shen-Orr, Z., Jimenez, M., Stannard, B., Wang, L.-M., Pierce, J., and LeRoith, D. (1996) The proto-oncogene c-Crk associates with IRS-1 and 4PS and enhances IGF-I signaling. J. Biol. Chem, 271:9287-9290.

19. Rani, C.S., Su, Y., Berger, A., Wu, J., Beitner-Johnson, D., Sturgill, T.W., Varicovski, L., LeRoith, D., and Spiegel, S. (1997) Divergence in signal transduction pathways of PDGF and EGF receptors: involvement of sphingosine-1-phosphate in PDGF but not EGF signaling. J. Biol. Chem, 272: 10777-10783.

20. Blakesley, V.A., Beitner-Johnson, D., C.S. Rani, Shen-Orr, Z., Stannard, B., Spiegel, S., and LeRoith, D. (1997) Sphingosine-1-phosphate stimulates tyrosine phosphorylation of Crk. J. Biol. Chem, 272: 16211-16215.

21. Parrizas, M., Blakesley, V.A., Beitner-Johnson, D. and LeRoith, D. (1997) The proto-oncogene Crk-II enhances apoptosis by a ras-dependent, Raf-1/MAP kinase-independent pathway. Biochem. Biophys. Res. Commun., 234: 616-620.

22. Beitner-Johnson, D., Leibold, J., and Millhorn, D.E. (1998) Hypoxia regulates the cAMP- and Ca2+/CaM-signaling systems in PC12 cells. Biochem. Biophys. Res. Commun., 242: 61-66.

23. Beitner-Johnson, D. and Millhorn, D.E. (1998) Hypoxia induces phosphorylation of the cyclic AMP response element binding protein by a novel signaling mechanism. J. Biol. Chem. 273: 19834-19839.

24. Kobayashi, S., Beitner-Johnson, D., Conforti, L., and Millhorn, D.E. (1998) Chronic hypoxia reduces adenosine 2A receptor-mediated inhibition of calcium current in PC12 cells via down-regulation of protein kinase A. J. Physiol., 512: 351-363.

25. Conrad, P.W., Rust, R.T., Han, J., Millhorn, D.E., and Beitner-Johnson, D. (1999) Selective activation of p38a and p38g by hypoxia in PC12 cells: role in regulation of cyclin D1.  J. Biol. Chem., 274: 23570-23576.

26.  Kobayashi, S., Conforti, L., Beitner-Johnson, D., and Millhorn, D.E. (1999) Chronic hypoxia attenuates dopamine D2 receptor-mediated inhibition of Ca2+ current in PC12 cells via down-regulation of Gao, Pflugers Arch., 438: 750-759.

27.  Beitner-Johnson, D., Seta, K., Kim, H.-W., Yuan, Y. Conrad, P., Kobayashi, S., and Millhorn, D.E. (2001) Identification of hypoxia-responsive genes in a dopaminergic cell line by subtractive cDNA libraries and microarray analysis, Parkinsonism Relat. Disord., 7(3):273-281.

28.  Conrad, P.W., Millhorn, D.E, and Beitner-Johnson, D. (2000) Novel regulation of p38g by dopamine D2 receptors during hypoxia. Cell Signaling, 12: 463-467.

29.  Beitner-Johnson. D., Rust, R.T., Hsieh, T., and Millhorn, D.E. (2001) Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells. Cell Signalling, 13: 23-27.

30.  Seta, K., Kim, H.-W., Kim, R., Millhorn, D.E., and Beitner-Johnson, D. (2001) Hypoxia-induced regulation of MKP-1: identification by suppressive subtractive hybridization and cDNA microarray analysis. J. Biol. Chem., 276: 44405-44412.

31.Yuan, Y., Beitner-Johnson, D., and Millhorn, D.E. (2001) Hypoxia-inducible factor 2alpha binds to cobalt in vitro.  Biochem. Biophys. Res. Commun. 288: 849-854.

32. Beitner-Johnson, D., Rust, R.T., Kobayashi, S., and Millhorn, D.E. (2002) Calcium-dependent activation of Pyk2 by hypoxia in PC12 cells. Cell Signalling 14: 133-137.

32.  Tada, A., Pereira, E., Beitner-Johnson, D., and Abdel-Malek, Z.A. (2002) Mitogen- and ultraviolet-B-induced signaling pathways in normal human melanocytes. J. Invest. Dermatol. 118: 16-22.

 

Review Articles / Book Chapters:

1. Beitner-Johnson, D., Guitart, X., and Nestler, E.J. (1992) Common intracellular actions of chronic morphine and cocaine in dopaminergic brain reward regions. Ann NY Acad Sci, 654: 70-87.

2. Beitner-Johnson, D., and Nestler, E.J. (1992) Basic neurobiology of cocaine: actions within the mesolimbic dopamine system, In: The Clinician's Guide to Cocaine Addction: Theory, Research, and Treatment,ed. by T. Kosten, Guilford Press, New York.

3. Nestler, E.J. and Beitner-Johnson, D. (1992) Common biochemical mechanisms underlying opiate and cocaine addiction. Drug News and Perspectives, 5: 214-222.

4. Nestler, E.J., Guitart, X., and Beitner-Johnson, D. (1993) Second messenger and protein phosphorylation mechanisms underlying opiate and cocaine addiction. In: The Biological Basis of Substance Abuse, ed. by S.G. Koreneman and J.D. Barchas, Oxford University Press.

5. LeRoith, D., Werner, H., Beitner-Johnson, D., and Roberts, C.T., Jr. (1994) Molecular biology of the IGF-I receptor, In: Growth Hormone, IGF-I and Growth: A Modern View of Old Concepts, eds. Z. Laron and T. Merimee, Karger.

6. Werner, H., Beitner-Johnson, D., Roberts, C.T., Jr., and LeRoith, D. (1994) Molecular comparisons of the insulin and IGF-I receptors, In: Molecular and Cellular Aspects of Diabetes Mellitus, eds. B. Draznin and D. LeRoith, Humana.

7. LeRoith, D., Werner, H., Beitner-Johnson, D., and Roberts, C.T., Jr. (1995) Molecular and cellular aspects of the insulin-like growth factor-I receptor. Endocrine Rev, 16: 1-21.

8. Millhorn, D.E., Raymond, R., Conforti, L., Zhu, W., Beitner-Johnson, D., Filisko, T., Genter, M.B., Kobayashi, S., and Peng, M. (1996) Regulation of gene expression for tyrosine hydroxylase in oxygen-sensitive cells by hypoxia. Kidney International, 51: 527-535.

9. Millhorn, D.E., Conforti, L., Beitner-Johnson, D., Zhu, W., Raymond, R., Filisko, T., Kobayashi, S., Peng, M., and Genter, M.B. (1996) Regulation of ionic conductances and gene expression by hypoxia in an oxygen sensitive cell line. In: Frontiers in Arterial Chemoreception. Eds. P. Zapata, C. Eyzaguirre, and R. Torrance, Plenum Press, New York.

10. Beitner-Johnson, D., Shull, G., Dedman, J., and Millhorn, D.E. (1997) Regulation of gene expression by hypoxia: a molecular approach. Resp. Physiol. 110: 87-97.

11. Conforti, L., S. Kobayashi, Beitner-Johnson, D., P.W. Conrad, T. Freeman, and Millhorn, D.E. (1999) Regulation of gene expression and secretory functions in oxygen-sensing pheochromocytoma cells.  Resp. Physiol. 115: 249-260.

12. Conrad, P.W., Conforti, L., Kobayashi, S., Beitner-Johnson, D., Rust, R.T., Yuan, Y., Kim, H.W., Kim, R.H., Seta, K., Millhorn, D.E. (2001) The molecular basis of O2-sensing and hypoxia tolerance in pheochromocytoma cells. Comp Biochem Physiol B Biochem Mol Biol. 128(2):187-204. 

 

 

 

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